KMID : 0357920130470040332
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Korean Journal of Pathology 2013 Volume.47 No. 4 p.332 ~ p.339
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SIRT1 Expression Is Associated with Good Prognosis in Colorectal Cancer
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Jung Won-Kyung
Hong Kwang-Dae Jung Woon-Yong Lee Eun-Jung Shin Bong-Kyung Kim Han-Kyeom Kim Ae-Ree Kim Baek-Hui
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Abstract
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Background: Silent mating type information regulation 2 homolog 1 (SIRT1), an NAD+-dependent deacetylase, might act as a tumor promoter by inhibiting p53, but may also as a tumor suppressor by inhibiting several oncogenes such as ¥â-catenin and survivin. Deleted in breast cancer 1 (DBC1) is known as a negative regulator of SIRT1. Methods: Immunohistochemical expressions of SIRT1, DBC1, ¥â-catenin, surviving, and p53 were evaluated using 2 mm tumor cores from 349 colorectal cancer patients for tissue microarray. Results: Overexpression of SIRT1, DBC1, survivin, and p53 was seen in 235 (67%), 183 (52%), 193 (55%), and 190 (54%) patients, respectively. Altered expression of ¥â-catenin was identified in 246 (70%) patients. On univariate analysis, overexpression of SIRT1 (p=0.029) and altered expression of ¥â-catenin (p=0.008) were significantly associated with longer overall survival. Expression of SIRT1 was significantly related to DBC1 (p=0.001), ¥â-catenin (p=0.001), and survivin (p=0.002), but not with p53. On multivariate analysis, age, tumor stage, differentiation, and expression of SIRT1 were independent prognostic factors significantly associated with overall survival. Conclusions: SIRT1 overexpression is a good prognostic factor for colorectal cancer, and SIRT1 may interact with ¥â-catenin and survivin rather than p53.
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KEYWORD
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Colon, Adenocarcinoma, SIRT1, DBC1, Beta catenin
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